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Reversal of slow growth and heartbeat through the restoration of mitochondrial function in clk-1-deficient mouse embryos by exogenous administration of coenzyme Q10.
Takahashi M, Shimizu T, Shirasawa T. Takahashi M, et al. Exp Gerontol. 2012 Jun;47(6):425-31. doi: 10.1016/j.exger.2012.03.008. Epub 2012 Mar 22. Exp Gerontol. 2012. PMID: 22465812
However, whether the mammalian clk-1/coq7 ortholog (clk-1) regulates these phenotypes in mammals remains to be fully evaluated due to the embryonic lethality of clk-1-deficient (clk-1(-/-)) mice. ...In embryonic cells, cardiomyocytes, and hearts, the growth a …
However, whether the mammalian clk-1/coq7 ortholog (clk-1) regulates these phenotypes in mammals remains to be fully evaluated due to …
Ubiquinone is necessary for mouse embryonic development but is not essential for mitochondrial respiration.
Levavasseur F, Miyadera H, Sirois J, Tremblay ML, Kita K, Shoubridge E, Hekimi S. Levavasseur F, et al. J Biol Chem. 2001 Dec 7;276(49):46160-4. doi: 10.1074/jbc.M108980200. Epub 2001 Oct 3. J Biol Chem. 2001. PMID: 11585841 Free article.
We find that mclk1-/- embryonic stem cells and embryos accumulate DMQ instead of UQ. As in the nematode mutant, the activity of the mitochondrial respiratory chain of -/- embryonic stem cells is only mildly affected (65% of wild-type oxygen consumption). ...These fi …
We find that mclk1-/- embryonic stem cells and embryos accumulate DMQ instead of UQ. As in the nematode mutant, the activity of the m …